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Dushyant Patel Introduction

S.K.P.C.P.E.R., Kherva 3 M .Pharm. Thesis

as secondary generalization. Generalized seizures are divided according to the effect on

the body but all involve loss of consciousness. These include absence (petit mal),

myoclonic, clonic, tonic, tonic-clonic (grand mal) and atonic seizures.

1.1.5 TREATMENT

8-14:

¾ Epilepsy is usually treated with medication prescribed by a physician; primary

caregivers, neurologists, and neurosurgeons all frequently care for people with epilepsy.

In some cases the implantation of a stimulator of the vagus nerve, or a special diet can be

helpful. Neurosurgical operations for epilepsy can be palliative, reducing the frequency

or severity of seizures; or, in some patients, an operation can be curative.

1.1.5.1 Medication for Epilepsy:

1. Drugs acting through Na

channels

Examples:

¾ Phenytoin

¾ Diphenylhydantoin (DPH)

¾ Phenobarbitone

¾ Trimethadione

¾ Carbamazepine

¾ Lamotrigine

2. Drugs acting through GABA

Examples:

¾ Sodium valproate

¾ Diazepan and Clonazepam

¾ Midazolam

¾ Gabapentin

¾ Vigabatrin

¾ Clobazam

3. Drugs acting through NMDA receptor inhibition

Examples:

¾ Flunarizine

¾ Zonisamide

¾ Topiramate

4. Non pharmacological therapy

Examples:

¾ Vagus nerve stimulation

¾ Ketogenic diet

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